WebAug 23, 2016 · Type 2 diabetes mellitus is a growing pandemic and a leading cause of morbidity and mortality. 1 After the DCCT (Diabetes Control and Complications Trial) 2 found that tight glycemic control–a … WebACCORD / ADVANCE / VADT / ORIGIN / TECOS – T2D 39. Tired of all the controversy, and still confident of the benefits of blood glucose lowering, the National Institutes for Health in the United States funded a huge, ambitious randomized controlled trial involving over 10,000 patients called the Action to Control Cardiac Risk in Diabetes ...
Review of the veteran affairs diabetes trial: Lessons learned
WebJun 29, 2010 · ACCORD examined whether intensive treatment with an even lower targeted HbA 1c (less than 6·0%) versus standard treatment (targeted HbA 1c 7·0–7·9%) would reduce the risk of morbidity and mortality from cardiovascular disease (primary endpoint) and microvascular events, such as the incidence of photocoagulation treatment for … WebJan 1, 2009 · The evidence for a cardiovascular benefit of intensive glycemic control remains strongest for those with type 1 diabetes. However, subset analyses of ACCORD, ADVANCE, and VADT suggest the hypothesis that patients with shorter duration of type … rockwiz band members
New insights into the mechanisms of diabetic complications
WebThe Action to Control Cardiovascular Risk in Diabetes (ACCORD)-Lipid trial tested the hypothesis that combination therapy with a fibrate and statin would more effectively … WebThe honest answer is that we simply do not know. The findings from the ACCORD, ADVANCE, and VADT demonstrate that aggressive Hb A1C lowering to near-normal levels in patients with type 2 diabetes is not beneficial for the prevention of CVD events in general, [5-7] and may even be harmful in some patient populations.[5] WebJun 4, 2024 · Glucose control and vascular complications in veterans with type 2 diabetes. N Engl J Med. 2009;360:129-139. doi: 10.1056/NEJMoa0808431. 5. Patel A, MacMahon S, Chalmers J, et al, for The ADVANCE Collaborative Group. Intensive blood glucose control and vascular outcomes in patients with type 2 diabetes. otter footprints