Elongin-cullin-socs-box protein

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August undefined, 2024

WebThe largest family of SOCS box-containing proteins is the ankyrin repeat and SOCS box-containing (ASB) protein family. Members of the ASB family include ASB-1 through ASB-18 and are involved in a variety of biological processes. ... (Elongin-Cullin-SOCS-box protein) E3 ubiquitin protein ligase complex. This complex mediates the ubiquitination ... Web1993; Aso et al., 1995). In the ECS complex, Elongin C and the small ubiquitin-like protein Elongin B connect the cullins CUL2 or CUL5 to the substrate recognition module that …

The role of cullin 5-containing ubiquitin ligases - Cell Division

WebMay be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and … WebMay 16, 2006 · Overall, the SOCS box and SH2 domain show a conserved spatial domain arrangement with the BC box and substrate recognition domain of the von Hippel-Lindau (VHL) tumor suppressor protein, suggesting a common mechanism of ubiquitination in these cullin-dependent E3 ligases. The SOCS box binds elongin BC in a similar … c6 corvette cross over pipe hard to replace

Biomedicines Free Full-Text The ElonginB/C-Cullin5 …

WebCullin-RING ligase 5 (CRL5) is a multi-protein complex and consists of a scaffold protien cullin 5, a RING protein RBX2 (also known as ROC2 or SAG), adaptor proteins … WebSubstrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes at least two forms of creatine kinase, CKB and CKMT1A. This gene encodes a member of the ankyrin repeat and … WebNov 5, 2024 · The two most characteristic subfamilies of CRLs are the Skp1-cullin-F-box (SCF) and elongin-C-cullin-SOCS-box families, with the latter including the SOCS box-containing proteins and the von Hippel-Lindau (VHL) tumor suppressor. ... For CRL5, the RING E3 ligase connector may be elongin B/C and the substrate-binding protein may … c6 corvette diff cooler fittings

The ElonginB/C-Cullin5-SOCS-Box-Complex Is a Potential ... - PubMed

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WebJan 23, 2007 · Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins (PubMed:23806657). As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin … WebX-ray crystallography and biochemical studies have defined that the C-terminal 40 amino acid domain of the SOCS proteins, termed the SOCS box, interacts with Elongin B and Elongin C, Cullin-5 and RING-box-2 (RBX2) to form an E3 ligase complex termed ECS (Elongin B/C–Cullin–SOCS box protein) [166, 167] (Figure 64.3). c6 corvette charging portsWebDescription: Homo sapiens TUB like protein 4 (TULP4), transcript variant 1, mRNA. (from RefSeq NM_020245) Gencode Transcript: ENST00000367097.8 Gencode Gene: ENSG00000130338.13 Transcript (Including UTRs) c6 corvette cooling fans

"WebElongin BC and Cullin 5 are recruited directly to specific motifs in the SOCS box domain as part of a complex containing Ring box protein 2 (Rbx2) and a ubiquitin conjugating enzyme (E2) . Once the E3 ubiquitin ligase complex is assembled, target proteins bound through the SH2 domain undergo ubiquitination, leading to their proteasomal ... " - Elongin-cullin-socs-box protein

Elongin-cullin-socs-box protein

ORF73 interacts with Cullin5 and ElonginC through its …

WebMay 16, 2006 · By analogy with the von Hippel–Lindau (VHL) protein, which binds elongin BC to target hypoxia-inducible factor (HIF-1α) for proteasomal degradation (12, 13), it is … WebMay 18, 2007 · The SOCS box interacts with elongin B and elongin C, cullin-5 and RING-box-2 (RBX2), which recruits E2 ubiquitin transferase 8. CIS–SOCS-family proteins, as well as other SOCS-box-containing ...

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WebOct 21, 2013 · The tumor suppressor VHL (von Hippel–Lindau) protein is a substrate receptor for Ubiquitin Cullin Ring Ligase complexes (CRLs), containing a BC-box domain that associates to the adaptor Elongin B/C. … WebMar 1, 2001 · Function. May be a substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which …

WebDec 12, 2024 · We demonstrate that ELC-2 and the von Hippel-Lindau protein VHL-1, components of an Elongin-Cullin-SOCS box (ECS) E3 ubiquitin ligase, modulate this … WebCullin-5; Core component of multiple SCF-like ECS (Elongin-Cullin 2/5-SOCS-box protein) E3 ubiquitin-protein ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. As a scaffold protein may contribute to catalysis through positioning of the substrate and the ubiquitin- conjugating …

WebTarget Information: Probable substrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins Supplier Page. Supplier Page from antibodies-online for anti-RAB40C Antibody. WebHome; Products. Featured Collections. Recombinant Rabbit Monoclonal Antibodies; IHC/Pathology Antibodies; KO Validated Antibodies; Antibodies. Primary Antibodies

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WebSubstrate-recognition component of a SCF-like ECS (Elongin-Cullin-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent … clove oil chemist warehouseWebMar 9, 2016 · The suppressor of cytokine signaling (SOCS) box consists of the BC box and the cullin 5 (Cul5) box, which interact with Elongin BC and Cul5, respectively. SOCS box-containing proteins have ubiquitin ligase activity mediated by the formation of a complex with the scaffold protein Cul5 and the RING domain protein Rbx2, and are thereby members … c6 corvette differential rebuild kitWebDespite the large number of mammalian F-box proteins, in addition to β-TRCP1/2 and FBW7, only one other mammalian F-box protein has been matched to its downstream substrates, namely, SKP2 (Ang and Harper 2004; Cardozo and Pagano 2004).Interestingly, SKP2 is the product of a proto-oncogene, FBW7 is a tumor suppressor (Pagano and … c6 corvette cooling upgradeWebNov 5, 2024 · The two most characteristic subfamilies of CRLs are the Skp1-cullin-F-box (SCF) and elongin-C-cullin-SOCS-box families, with the latter including the SOCS box … c6 corvette flex plateWebMar 31, 2016 · Fawn Creek Township is located in Kansas with a population of 1,618. Fawn Creek Township is in Montgomery County. Living in Fawn Creek Township offers … clove oil bromine testWebThe suppressors of cytokine signaling (SOCS) are negative feedback inhibitors of cytokine and growth factor-induced signal transduction. The C-terminal SOCS box region is thought to regulate SOCS protein stability most likely via an elongin C interaction. In the present study, we have found that phosphorylation of SOCS3 at two tyrosine residues ... c6 corvette floor mats for saleWebApr 6, 2024 · In VHL-box E3 Ubiquitin ligases, VHL is bound to a heterodimer complex composed of Elongin B (ELOB) and Elongin C (ELOC) through the "BC-box motif" found in many proteins in the VHL-box and SOCS-box protein families. ELOB/ELOC serves as an adapter between substrate recognition proteins and Cullin-2 (or Cullin-5) and RBX1 to … clove oil breath freshener