Hippuristanol
WebMay 15, 2010 · Hippuristanol is a natural product that has recently been shown to inhibit eukaryotic translation initiation and tumor cell proliferation. To investigate the structure and activity relationship of ... WebSep 6, 2013 · Hippuristanol suppressed the activities of these three pathways by inhibiting the expression of JunB, JunD, c-Fos, signal transducers and activators of transcription protein 3 and Akt proteins. In a xenograft mouse model that showed ascites and diffused organ invasion of PEL cells, treatment with hippuristanol significantly inhibited the …
Hippuristanol
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WebSep 29, 2024 · Hippuristanol treatment (1 mM for 1 h) increased the number of TIA-1-positive stress granules that largely co-localized with INVERSIN and BICC1. In this experiment, a total of 19 z-stacks were ... WebMar 1, 2011 · Hippuristanol, as a pan eIF4A inhibitor, has been reported to inhibit human T lymphotrophic virus type 1-infected T-cell line and adult T-cell leukemia cell proliferation …
WebMoreover, given that the Sal treatments rendered unpromising results, we explored alternatives to sensitize cancer cells. Several small molecules known to disrupt eIF4A RNA helicase have been reported to possess anticancer activity both in vitro and in vivo, including rocaglates, hippuristanol, rohinitib, and pateamine A (PatA) [82,83]. Hippuristanol is a small molecule found in the coral Isis hippuris which was discovered by Jerry Pelletier and others of McGill University in Montreal, Quebec, Canada. It appears to have anti-viral activity and may hold promise as a cancer therapy. Binds to and inhibits the eukaryotic translation initiation factor protein eIF4A.
WebOct 2, 2014 · In addition, treatment with hippuristanol, a second inhibitor of eIF4A, produced similar results in our reporter assay (Additional file 6). Notably, the relatively unstructured 5' UTR of CyclinD1 ([DELA]G = -47 kcal/mol) (Figure S6a,b in Additional file 7) had little impact on the sensitivity of our reporter to eIF4A inhibition. WebHippuristanol – A selective inhibitor of eIF4A Hippuristanol is a member of one of 4 classes of poly-oxygenated steroids. These include (i) the hippurin or hippuristanol type …
WebHippuristanol C28H46O5 CID 9981822 - structure, chemical names, physical and chemical properties, classification, patents, literature, biological activities ...
incirlik newcomersWebJan 4, 2016 · Hippuristanol was used to inhibit eIF4A, as this causes a loss of both its RNA binding and its ATPase activity, by locking the protein in its closed confirmation [32], thereby achieving a loss of ... incirlik nuclear weaponsWebAug 7, 2024 · Hippuristanol (Hipp) is a natural product that selectively inhibits protein synthesis by targeting eukaryotic initiation factor (eIF) 4A, a DEAD-box RNA helicase … inbound llamadasWebMar 11, 2014 · Results suggest that the stereochemistry and all substituents of spiroketal portion (rings E and F) and C3-α and C11-β hydroxyl functional groups on rings A and C, respectively, are critical for the inhibitory activity of natural product 1. An efficient synthesis of hippuristanol (1), a marine-derived highly potent antiproliferative steroidal natural … inbound log inWebJan 4, 2016 · Hippuristanol is a member of one of 4 classes of polyoxygenated steroids. These include (i) the hippurin or hippuristanol type containing a spiroketal ring, (ii) the gorgosterol type containing a cyclopropane residue; (iii) the hippuristerone type possessing a 3-keto functionality, and (iv) the hippuristerol type (Fig. 2A). incirlik roadhouse menuWebJan 1, 2013 · Hippuristanol is a small-molecule inhibitor that significantly blocks eIF4A-eIF4F activity (Bordeleau et al. 2006). Using these two compounds, in the present study, we show here, for the first time, that specific inhibition of eIF4F-mediated activities blocks the expression of protein synthesis-dependent long-term potentiation (LTP) in the ... incirlik post officeWebMar 15, 2011 · We evaluated the anti-adult T-cell leukemia (ATL) effects of hippuristanol, an eukaryotic translation initiation inhibitor from the coral Isis hippuris. Hippuristanol inhibited proliferation of HTLV-1-infected T-cell lines and ATL cells, but not normal peripheral blood mononuclear cells. It induced cell cycle arrest during G 1 phase by reducing ... incirlik translation