WebAt the tissue level, Siglec-8 mRNA was found to be most highly expressed in lung, PBMCs, spleen, and kidney. Two splice variants of Siglec-8 exist. The initially characterized form … Consistent with the role of most siglecs and the presence of the intracellular ITIM, Siglec-8 has been found to function as an inhibitory immunoregulatory receptor. Ligation of Siglec-8 induces cell death in eosinophils, and, surprisingly, the normally pro-survival cytokines interleukin (IL)-5 and GM-CSF have been found to potentiate this cell death effect. IL-33, which activates and maintains eosinophils, also exerts a similar potentiating effect on Siglec-8-induced cell death. Inhibitor stud…
Anti-SIGLEC8 antibody produced in rabbit Prestige Antibodies …
WebWestern Blot: Siglec-8 Antibody [NBP1-31141] - A: A431 7.5% SDS PAGE SIGLEC8 antibody diluted at 1:1000 The HRP-conjugated anti-rabbit IgG antibody (NBP2-19301) was used to … WebThe target protein is expressed with sequence (Met17-Thr546) of Human Siglec 10 fused with hFc and Avi tag at the C-terminal. Bio-Activity Storage Store the lyophilized protein at -20°C to -80°C for long term. After reconstitution, the protein solution is stable at -20°C for 3 months, at 2-8°C for up to 1 week. Avoid repeated freeze/thaw ... cytherea designer
Anti-SIGLEC8 antibody - C-terminal (ab198690) Abcam
WebEach Siglec-8 Antibody is fully covered by our Guarantee+, to give you complete peace of mind and the support when you need it. Our Siglec-8 Antibodies can be used in a variety … WebAn anti-Siglec-8 antibody described herein may comprise any suitable framework variable domain sequence, provided that the antibody retains the ability to bind human Siglec-8. … WebJan 30, 2024 · Urabrelimab (SRF231) is an anti-CD47 monoclonal antibody, blocking the CD47-SIRPα interaction. It has the potential to research anticancer. From 11:00 pm to 12:00 pm EST ( 8:00 pm to 9:00 pm PST ) on January 6th, the website will be under maintenance. bind unexpected end of input