Web29. máj 2024 · We examined the effects of spironolactone on weight, diuretic use, and renal function, and their subsequent impact on outcomes. Methods and results We analysed data from TOPCAT Americas (1767 patients with HF and preserved ejection fraction; 886 in spironolactone, 881 in placebo arm). Web15. mar 2024 · The study cohort comprised 3835 patients with HFpEF (3479 from I-Preserve and 356 from TOPCAT-Americas), of which 719 (19%) had AF on their baseline ECG (597 from I-Preserve and 122 from TOPCAT-Americas). Median (Q1–Q3) NT-proBNP concentration was 1286 pg/mL (778–2072) in those with AF and 288 pg/mL (122–704) in …
TopCat Rating - International cat rating system
Web18. máj 2024 · A total of 1746 (out of 1767; 99%) patients from TOPCAT‐Americas were available for the analyses with a median follow up of 2.4 (25th to 75th percentile 1.4–3.9) years. Web6. júl 2024 · In this issue of the Journal, Ferreira and colleagues, in a post-hoc analysis of the TOPCAT Americas cohort of patients with HFpEF, provide additional insights on the titration and discontinuation of spironolactone and the dose–response association between spironolactone and clinical events. 15 Ferreira et al. report that, during the first year … the canary girls
Cardiac structure and function and quality of life associations in ...
Web16. máj 2024 · Patients from the Americas TOPCAT cohort with DM (N=788) were clustered using agglomerative clustering. Kaplan-Meier (KM) analyses examined differences in the rates of primary composite outcome, all-cause mortality, and cardiovascular mortality between and within clusters. Results Web15. dec 2024 · Trials analysed – ATMOSPHERE, PARADIGM -HF, PARAGON -HF & TOPCAT -Americas. p-values for all differences <0.001. Maximum possible score 100. Lower score … Web1. mar 2024 · In 1,767 patients randomized to spironolactone or placebo in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial)-Americas study, we examined the incidence of WRF (doubling of serum creatinine) by treatment assignment. tattle and tale