site stats

Topcat americas

Web29. máj 2024 · We examined the effects of spironolactone on weight, diuretic use, and renal function, and their subsequent impact on outcomes. Methods and results We analysed data from TOPCAT Americas (1767 patients with HF and preserved ejection fraction; 886 in spironolactone, 881 in placebo arm). Web15. mar 2024 · The study cohort comprised 3835 patients with HFpEF (3479 from I-Preserve and 356 from TOPCAT-Americas), of which 719 (19%) had AF on their baseline ECG (597 from I-Preserve and 122 from TOPCAT-Americas). Median (Q1–Q3) NT-proBNP concentration was 1286 pg/mL (778–2072) in those with AF and 288 pg/mL (122–704) in …

TopCat Rating - International cat rating system

Web18. máj 2024 · A total of 1746 (out of 1767; 99%) patients from TOPCAT‐Americas were available for the analyses with a median follow up of 2.4 (25th to 75th percentile 1.4–3.9) years. Web6. júl 2024 · In this issue of the Journal, Ferreira and colleagues, in a post-hoc analysis of the TOPCAT Americas cohort of patients with HFpEF, provide additional insights on the titration and discontinuation of spironolactone and the dose–response association between spironolactone and clinical events. 15 Ferreira et al. report that, during the first year … the canary girls https://veedubproductions.com

Cardiac structure and function and quality of life associations in ...

Web16. máj 2024 · Patients from the Americas TOPCAT cohort with DM (N=788) were clustered using agglomerative clustering. Kaplan-Meier (KM) analyses examined differences in the rates of primary composite outcome, all-cause mortality, and cardiovascular mortality between and within clusters. Results Web15. dec 2024 · Trials analysed – ATMOSPHERE, PARADIGM -HF, PARAGON -HF & TOPCAT -Americas. p-values for all differences <0.001. Maximum possible score 100. Lower score … Web1. mar 2024 · In 1,767 patients randomized to spironolactone or placebo in the TOPCAT (Treatment of Preserved Cardiac Function Heart Failure With an Aldosterone Antagonist Trial)-Americas study, we examined the incidence of WRF (doubling of serum creatinine) by treatment assignment. tattle and tale

TOPCAT - Spironolactone in HFpEF — NERDCAT

Category:Ambulatory Worsening of Renal Function in Heart Failure With …

Tags:Topcat americas

Topcat americas

TOPCAT - Spironolactone in HFpEF — NERDCAT

WebGiven potential benefits in the Americas subgroup in TOPCAT, mineralocorticoid receptor antagonists can be considered in appropriately selected patients with HFpEF to reduce risk of heart failure ... Web3. dec 2014 · TOPCAT (Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist) was a randomized, double-blind, placebo-controlled trial of spironolactone for the treatment of heart failure with preserved ejection fraction (HFpEF) in 3,445 patients in six countries.

Topcat americas

Did you know?

Web6. júl 2024 · Finally, the doses of spironolactone used in TOPCAT are not commercially available, requiring clinicians be willing to adapt. Until further prospective data are … Web25. feb 2024 · The study authors performed latent-class analysis to identify heart failure with preserved ejection fraction (HFpEF) phenogroups based on standard clinical features, and …

http://en.top-cat.org/ Web1. apr 2024 · In TOPCAT-Americas HR-QoL was associated with cardiac structure and function alterations, particularly measures reflection cardiac mass and atrial volume. • …

Web1. apr 2024 · We also performed a separate analysis in Americas cohort of TOPCAT trial to validate the performance of risk scheme. The event rates and hazard ratio of composite safety endpoint were assessed across risk categories. Patients’ medication adherence in each group is described in Supplemental Table 11. Web18. nov 2013 · The TOPCAT trial showed that spironolactone is not superior to placebo in improving CV outcomes in patients with HFpEF, with higher rates of hyperkalemia and …

WebThe trial was the Treatment of Preserved Cardiac Function Heart Failure with an Aldosterone Antagonist Trial, known as TOPCAT. This was a randomized controlled trial evaluating …

Web18. máj 2024 · The Americas cohort of the treatment of preserved cardiac function heart failure with an aldosterone antagonist (TOPCAT‐Americas) was used to evaluate the association between total leucocyte count and clinical outcomes in HFpEF. The primary outcome was a composite of aborted cardiac arrest, cardiovascular mortality, or … tattle amy hubermanWeb16. máj 2024 · Patients from the Americas TOPCAT cohort with DM (N=788) were clustered using agglomerative clustering. Kaplan-Meier (KM) analyses examined differences in the … tattle ashy binesWeb1. mar 2024 · The data from TOPCAT suggest that WRF in the spironolactone group is not merely a diuretic effect, but rather some fundamental change in cardiorenal physiology … the canal systemWebNational Center for Biotechnology Information tattle asher mary louWeb26. sep 2015 · In the Americas, spironolactone was clearly superior to placebo in reducing cardiovascular events. Given these data from TOPCAT, basic science evidence for the role of aldosterone in HFpEF, and results from other MRA clinical trials in HFpEF, we advocate using spironolactone in HFpEF with close monitoring of potassium and renal function. tattle ashfordWebThe GDPR officially entered into force on May 25, 2024, and the Top Cat Rating team assumed a voluntary obligation to comply with all its principles and requirements from the … tattle aslWeb15. dec 2024 · Trials analysed – ATMOSPHERE, PARADIGM -HF, PARAGON -HF & TOPCAT -Americas. p-values for all differences <0.001. Maximum possible score 100. Lower score = worse HRQL. 27 tattle asher